Acceptable Daily Intake
Acceptable Daily Intake (ADI) is the "Quantity of a food additive that can be ingested daily, over a lifetime, without any risk (expressed in milligrams additive per kilogram body weight)." [1]
The term Acceptable Daily Intake (ADI) is used by the World Health Organization (WHO) and "other national and international health authorities and institutes" to describe exposure limits of toxic chemicals. [2]
The term "tolerable daily intake" (TDI) is used by the International Program on Chemical Safety (IPCS) and the "new term 'permitted daily exposure' (PDE) is defined in the present [1997] guideline as a pharmaceutically acceptable intake of residual solvents to avoid confusion of differing values for ADI's of the same substance." [3]
"For an ADI, toxicity studies are conducted to determine a No Observed Effect Level or a No Observed Adverse Effect Level (NOAEL). The studies would be selected to represent the expected types of exposure. For colours, this would be oral exposure. A safety factor is then added to take into account species difference between test animals and humans and variability between individuals. This is typically taken as a 100 fold factor." [4]
"The bodies which set the ADIs are the WHO/FAO Joint Expert Committee on Food Additives (JECFA) at a global level, the Scientific Committee for Food (SCF) at EU level and/or a national body." [5]
